Eshmuno^® – the SMART resin for efficient downstream processing

In order to meet the challenges of today’s markets, biopharmaceutical companies need a competitive edge. Merck’s new Eshmuno^® line of products has been specially developed to make your downstream processing more productive – because downstream processing is the most time-consuming as well as most expensive process step in the manufacture of biological drugs. Eshmuno^® is a new and unique family of “SMART” ion-exchange resins specifically designed for highly productive downstream purification of monoclonal antibodies (mAb).

The SMART solution – your benefits
Superior productivity for downstream processing More selectivity and HCP removal Active tentacle adsorption Robust and safe packing procedures Tangible cost and time savings
	Active Tentacle technology of Eshmuno®

Superior productivity with Eshmuno^®: Effective binding at higher flow rates

Decades ago, Merck KGaA was the first to offer ion-exchange resins with an innovative tentacle structure that is able to bind target substances much more effectively. Eshmuno^® combines this superior tentacle technology with the advantages of a new hydrophilic polyvinyl ether base matrix.

This combination allows the use of much higher flow rates while the biomolecule is still strongly bound by the tentacle.

Considerable cost and time savings with Eshmuno^®

In addition to its high binding capacity and excellent pressure-flow behavior, Eshmuno^® features a high selectivity and flexibility for the specific purification challenge, making it the most efficient resin available for HCP removal. Using Eshmuno^®, you can achieve an outstanding productivity in your downstream processing, resulting in substantial savings in development time and manufacturing costs.

Eshmuno^®: Robust and safe packing procedures

Eshmuno^® can be easily packed into production scale columns for biochromatography either by simple flow packing or axial compression. To prevent corrosion of the tubing system, Eshmuno^® columns can be packed using 0.01 M sodium hydroxide solutions and even pure water resulting in plate numbers > 2400/m with good peak symmetry.

For more information, please contact us.